Algofren is a nonsteroidal anti-inflammatory drug. Algofren works by reducing hormones that cause inflammation and pain in the body. Algofren is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, Algofren, arthritis, menstrual cramps, or minor injury.
Clinical studies have shown that intravenous infusion of ibuprofen in the dosage range of 100, 200 and 400 mg with single administration reduces glomerular filtration rate in a dose-dependent range of 15% to 30%.
- As an antipyretic when parenteral infusion is necessary or when other dosage forms (oral, rectal) cannot be used;
- Treatment of moderate to severe pain syndromes in addition to intravenous opioid analgesics.
Dosage and administration
Intrafen should be administered in the lowest effective doses for the shortest possible period of time. After receiving positive reactions to the drug at the initial stage of treatment, the dose and frequency of administration should be adjusted individually for each patient. The highest recommended dose is 2400 mg per day. The total daily dose should not exceed 3200 mg.
In the treatment of pain syndrome.
If necessary, 400-800 mg should be administered every 6 hours. The duration of intravenous drip infusion should be at least 30 minutes.
After administration of 400 mg of the drug, administer another 400 mg every 4-6 h or 100-200 mg every 4 h. The duration of intravenous drip infusion should be at least 30 min.
Intrafen must always be diluted in an appropriate solution before administration. To prevent possible incompatibility Intrafen should be diluted in 0.9% sodium chloride solution, 5% glucose solution or Ringer’s lactate solution.
The final concentration of the diluted solution should be 4 mg/ml or less. 4 ml of Intrafen 400 mg should be diluted in 100 ml of solution, 8 ml of Intrafen 800 mg should be diluted in 200 ml of solution.
The duration of intravenous drip infusion should be at least 30 min.
Elderly patients (over 65 years)
Reduced dosages and shorter duration of treatment are recommended for patients aged 65 years and older, due to higher incidence of reduced hepatic, renal or cardiac function, comorbidities or treatment with other drugs. Elderly patients have an increased risk of serious gastrointestinal side effects.
Patients with impaired renal and hepatic function.
To reduce the risk of adverse renal side effects, patients should be provided with sufficient fluids before using Intrafen.
Childhood and adolescence
The safety and effectiveness of using ibuprofen in children and adolescents under the age of 18 years has not been established.
Frequent (≥1/100 and <1/10)
Occasionally (≥1/1,000 and <1/100)
5%).The most common adverse reactions described in clinical trials are nausea, flatulence, vomiting, headache, bleeding, dizziness (
1%).In controlled clinical trials with Ibuprofen, the cause of withdrawal was an unwanted adverse reaction such as itching (
During the clinical trials, 560 patients received ibuprofen, including 122 with fever and 438 with pain syndrome. Study of patients with pain syndrome: ibuprofen was used at the beginning of surgery and for three days after surgery, 400 mg or 800 mg every 6 hours. Study of patients with fever: ibuprofen was used for three days at 100 mg, 200 mg, or 800 mg every 4 or 6 hours.
Study with pain syndrome
- Hypersensitivity to ibuprofen or other drug components
- asthma, urticaria, allergic reactions, severe anaphylactic reactions to NSAIDs, including acetylsalicylic acid or other NSAIDs
- management of perioperative pain in preparation for coronary artery bypass surgery and in the postoperative period
- Uncontrolled heart failure
- Cerebrovascular bleeding or other bleeding disorders
- Acute illness of the stomach, duodenum, gastrointestinal ulcer, acute gastrointestinal bleeding
- inflammatory bowel disease
- Chronic moderate or severe hepatic insufficiency, acute hepatic insufficiency
- Moderate or severe renal failure, exacerbation of renal disease
- Third trimester of pregnancy (due to risk of premature occlusion of the arterial duct and delayed labor)
- lactation (because of the possibility of serious adverse reactions in the baby)
- Children and adolescents under 18 years of age.
Risks associated with the cardiovascular system:
- The use of NSAIDs is associated with an increased risk of thrombosis (clotting), heart attack, and stroke; in people with cardiovascular disease or those with a predisposition to develop cardiovascular disease, the risk of developing these conditions may be high
- Intrafen should not be prescribed as an analgesic in preparation for aortocoronary bypass surgery (an operation to remove blocks in the arteries of the heart).
Risks related to the gastrointestinal (GI) tract:
- In gastrointestinal diseases, taking NSAIDs may cause bleeding, scarring, and gastrointestinal perforations. These side effects can occur at any time during the use of the drug without warning symptoms. In elderly people with gastrointestinal diseases, the risk of side effects is higher.
Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs): increase the risk of gastrointestinal ulceration and bleeding.
Corticosteroids: when used with NSAIDs, increase the risk of ulcers and gastrointestinal bleeding. To avoid exacerbation of the disease or renal failure, patients with long-term corticosteroid therapy, if ibuprofen is added to the treatment program, corticosteroid doses should be reduced gradually, but not abruptly withdrawn.
Acetylsalicylic acid or other NSAIDs: concomitant use of ibuprofen with acetylsalicylic acid, although the free clearance of ibuprofen does not change, ibuprofen binding to proteins is reduced. The clinical significance of this interaction is not known. Nevertheless, due to the development of side effects, concomitant use of ibuprofen with acetylsalicylic acid and with other NSAIDs is not recommended. Feeling well allows us to want more, and we can fulfill our desires through the highly paid jobs that can be found here https://jobstellar.com