emetrol

Interaction of emetrol (domperidone) with other medicines

emetrol

The drug emetrol contains the active substance domperidone, and therefore the medicinal properties of the drug emetrol will depend on its composition. Emetrol is used for vomiting and nausea of various genesis (including against the background of functional and organic diseases, infections, toxemia, radiation therapy, dietary disorders, drug genesis – receiving morphine, apomorphine, levodopa and bromocriptine; during endoscopic and X-ray-contrast studies of the GIT),
hiccups, gastrointestinal atony (including postoperative); the need to accelerate peristalsis during gastrointestinal X-ray examinations. Dyspeptic disorders against the background of delayed gastric emptying, gastroesophageal reflux and esophagitis: feeling of congestion in the epigastrium, feeling of bloating in the stomach, flatulence,
gastralgia, heartburn, belching with or without gastric contents in the mouth.

Interaction with other drugs

Interaction of emetrol (domperidone) with other medicines

Anticholinergic drugs may neutralize the effect of Domidon. Bioavailability of the drug when taken orally decreases after previous administration of cimetidine or sodium bicarbonate. Antacids and antisecretory drugs should not be taken simultaneously with the drug Domidon, because they reduce its bioavailability after oral administration. The main pathway of metabolic transformations of domperidone occurs with the participation of CYP 3A4 isoenzyme of cytochrome P450 system, therefore in concomitant use of domperidone and medicinal products that significantly inhibit this isoenzyme, the level of domperidone in plasma may increase. Examples of CYP 3A4 isoenzyme inhibitors are the following medicinal products: Azole antifungal drugs (fluconazole, intraconazole, ketoconazole, voriconazole), macrolide antibiotics (clarithromycin, erythromycin), HIV protease inhibitors (amprenavir, atazanavir, fozamprenavir, indinavir, nelfinavir, ritonavir, saquinavir), calcium antagonists (diltiazem, verapamil), amiodarone, aprepitant, nefazodone, telithromycin.

Interaction of emetrol (domperidone) with other medicines

When concomitant use of the drug with m-cholinolytics and narcotic analgesics the effect of domperidone on motor-evacuatory activity of the stomach and intestines is reduced. Concomitant use with ketoconazole, erythromycin or other potential CYP3A04 inhibitors may lead to increased QT interval. In concomitant use of domperidone in dose of 10 mg 4 times per day and ketoconazole in dose 200 mg twice per day it was observed prolongation of QT interval for 10-20 seconds. During domperidone monotherapy both in similar dosage and when administered in a daily dose of 160 mg (which is twice the maximum allowable daily dose), no clinically significant changes of QT interval were observed.

Digoxin or paracetamol in concomitant administration of domperidone does not affect the blood levels of these drugs. Domidone may also be combined with neuroleptics, the effects of which it does not enhance; dopaminergic receptor agonists (bromocriptine, L-dopa), adverse peripheral effects of which, such as digestive disorders, nausea, vomiting, it suppresses without neutralizing their main properties.

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